Murals in the Old Kent Road will be removed and put in storage if a demolition plan is approved.
The mosaics by Adam Kossowski (1905-1986) were completed in 1965 and adorn the former North Peckham Civic Centre.
Depicted are people known to have travelled the Roman road to and from Canterbury.
Adam Kossowski’s work is also found at two more places on the Pilgrims’ Way outside the capital.
At Otford in Kent, where the path from Winchester joins the main London way, the stations of the cross inside Holy Trinity Church are by Kossowski.
His most famous murals are at Aylesford Priory where he continued working on site until 1971 and is buried.
The plan for the Old Kent Road site is to replace the existing three storey building with a mixed use redevelopment
Only the large three panel ceramic mural, which wraps around the recessed ground floor frontage to Old Kent Road and Peckham Park Road, is listed.
This is Adam Kossowski’s only large secular work.
The planning application seeks to eventually install the murals at first floor level facing Old Kent Road in a high rise development. A present they can be viewed at ground level from the street.
Objections should be received by Thursday 15 November.